Development of DNA/RNA-based nanoscaffolds and nanostructures for imaging and drug-delivery


Francesco Ricci



Università degli Studi di Roma Tor Vergata



Development and optimization of synthetic DNA/RNA nanoscaffolds and nanostructures for drug delivery and imaging purposes. We will exploit the “designability” of nucleic acids to design molecular nanostructures and nanoscaffolds that respond to specific biomarkers and, in doing so, can i) signal the presence of a tumor marker or ii) release a therapeutic agent. The synthetic nanoscaffolds and nanostructures developed during the project will be decorated with different therapeutic agents or imaging agents and will respond to a wide range of molecular markers (antibodies, proteins, small molecules, etc.). The structures will allow the targeted delivery of specific therapeutic agents or the imaging of specific targets.

Relevant publications

  1. Bucci J, Irmisch P, Del Grosso E, Seidel R, Ricci F 
Timed Pulses in DNA Strand Displacement Reactions
J Am Chem Soc 2023, in press.

  2. Farag N, Đorđević M, Del Grosso E, Ricci F
    Dynamic and Reversible Decoration of DNA-Based Scaffolds
Advanced Materials, 35, 18, 2211274. 

  3. Bracaglia S, Ranallo S, Ricci F
Electrochemical cell-free biosensors for antibody detection
Angew Chem Int Ed, 2023, e202216512.

  4. Ranallo S, Bracaglia S, Sorrentino D, Ricci F
Synthetic Antigen-Conjugated DNA Systems for Antibody Detection and


Related Projects

PI: Massimo Olivucci