Development of synthetic strategies and software tools for the preparation of photo-modulable RNA aptamers for the control of translation

PI:

Massimo Olivucci

Email:

massimo.olivucci@unisi.it

Affiliation:

Università degli Studi di Siena

ORCID:

0000-0002-8247-209X

We propose to open a novel research line exploiting technologies shown to be effective for the automatic design and preparation of photo-responsive proteins. We plan to transfer/adapt such technologies to the design and preparation of photo-modulable RNA aptamers capable to optically control the translation at both the cellular and tissue levels. This proposal is complementary to the development of RNA-delivery tools and the synthesis of specific RNA sequences

Relevant publications

  1. Pedraza-González, L.; Barneschi, L.; Marszałek, M.; Padula, D.; De Vico, L.; Olivucci, M. Automated QM/MM Screening of Rhodopsin Variants with Enhanced Fluorescence J. Chem. Theory Comput. 2023, 19, 293-310. DOI: 10.1021/acs.jctc.2c00928

  2. Boeije, Y.; Olivucci, M. From a one-mode to a multi-mode understanding of conical intersection mediated ultrafast organic photochemical reactions Chem. Soc. Rev. 2023, 52, 2643-2687. DOI: 10.1039/D2CS00719C

  3. Ikonnikov, E.; Paolino, M.; Garcia-Alvarez, J. C.; Orozco-Gonzalez, Y.; Granados, C.; Röder, A.; Léonard, J.; Olivucci, M.; Haacke, S.; Kornilov, O.; Gozem, S. Photoelectron Spectroscopy of Oppositely Charged Molecular Switches in the Aqueous Phase: Theory and Experiment  J. Phys. Chem. Lett. 2023, 14, 6061-6070. DOI: 10.1021/acs.jpclett.3c00828

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