The impact of cell stress on alternative splicing

PI:

Alessandra Montecucco

Email:

alessandra.montecucco@igm.cnr.it

Affiliation:

The impact of cell stress on alternative splicing

ORCID:

0000-0002-9388-9149

My laboratory has been involved for a long time in the cell stress response, in particular in the cell response to DNA damage and metabolic stress. In the last ten years became evident that several pre-mRNA processing factors are regulated during the DNA damage response shifting the alternative splicing (AS) pattern of target genes to control cell survival. This finding highlighted the existence of a complex regulatory network that links AS decisions to DNA damage and metabolic stress. Currently, in collaboration with a veterinary company (AVANTEA s.r.l.) we are studying the impact of mutations of the RNA binding protein TDP-43 linked to the amyotrophic lateral sclerosis (ALS10) on the AS decision in cells from a Sus domesticus ALS model system.

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